The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article. Skip to Main Content. Search in: This Journal Anywhere. Advanced search. Journal Immunopharmacology and Immunotoxicology Volume 37, - Issue 4. Submit an article Journal homepage. Pages Received 03 Jan Additional information Declaration of interest The authors report no conflicts of interest. Article Metrics Views.
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Pdf Immunopharmacology Of Free Radical Species Handbook Of Immunopharmacology
Restore content access Restore content access for purchases made as guest. Article Purchase - Online Checkout. In addition, oxidative stress is a central regulator of HMGB1 translocation, release, and activity [ ]. ROS produced mainly by tumor cells and immunosuppressive cells in the tumor microenvironment may determine the activation, proliferation, differentiation, and apoptosis of antitumor T cells. Considering the ROS-mediated immunosuppressive mechanisms, an important implication of therapeutic strategy targeting ROS is using antioxidant agents or supplements which may regulate antitumor T cell responses.
Specifically, T cell-based therapy combined with ROS scavenger would improve clinical efficacy by enhancing expansion and function of antitumor T cells. Despite remarkable progress in recent years, the mechanism for the roles of ROS in T cell biology still remains unclear. Development of more effective strategies combining ROS manipulation and T cell-based therapy warrants further investigations particularly for the treatment of patients with advanced cancer. National Center for Biotechnology Information , U.
Oxid Med Cell Longev. Published online Jul Author information Article notes Copyright and License information Disclaimer. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This article has been cited by other articles in PMC.
Abstract Reactive oxygen species ROS produced by cellular metabolism play an important role as signaling messengers in immune system. Introduction Reactive oxygen species ROS are small short-live oxygen-containing molecules that are chemically highly reactive.
Immunopharmacology Of Free Radical Species Handbook Of Immunopharmacology
Open in a separate window. Figure 1. Figure 2. Conclusions and Perspectives ROS produced mainly by tumor cells and immunosuppressive cells in the tumor microenvironment may determine the activation, proliferation, differentiation, and apoptosis of antitumor T cells. Competing Interests The authors have no competing interests to disclose. References 1. Free radicals in the physiological control of cell function. Physiological Reviews. Trachootham D.
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Nature Reviews Drug Discovery. Cornelissen C. Ultraviolet B radiation and reactive oxygen species modulate interleukin expression in T lymphocytes, monocytes and dendritic cells. British Journal of Dermatology. Asano H. Nicotine- and tar-free cigarette smoke induces cell damage through reactive oxygen species newly generated by PKC-dependent activation of NADPH oxidase. Journal of Pharmacological Sciences. Ganeva M. Adverse drug reactions and reactive oxygen species.
Immunopharmacology of Free Radical Species - 1st Edition
Folia Medica. Afanas'ev I. Superoxide and nitric oxide in pathological conditions associated with iron overload: the effects of antioxidants and chelators. Current Medicinal Chemistry. Reth M. Hydrogen peroxide as second messenger in lymphocyte activation. Nature Immunology.
Winterbourn C. The biological chemistry of hydrogen peroxide. Methods in Enzymology. Kato Y. Neutrophil myeloperoxidase and its substrates: formation of specific markers and reactive compounds during inflammation. Journal of Clinical Biochemistry and Nutrition. Rhee S.
Cell signaling. H 2 O 2 , a necessary evil for cell signaling. Dickinson B. Chemistry and biology of reactive oxygen species in signaling or stress responses. Nature Chemical Biology.
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